Publications

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Schmidt, T.T., Tyer, C., Rughani, P., Haggblom, C., Jones, J.R., Dai, X., Frazer, K.A., Gage, F.H., Juul, S., Hickey, S., Karlseder, J. High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer. (2024) Nature Communications. 15(1):5149. DOI: 10.1038/s41467-024-48917-7

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Nassour, J., Przetocka, S., Karlseder, J. Telomeres as hotspots for innate immunity and inflammation. (2023) DNA Repair (Amst). 133:103591. DOI: 10.1016/j.dnarep.2023.103591

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Moreno, S.P., Fusté, J.M., Kaiser, M., Li, J.S.Z., Nassour, J., Haggblom, C., Denchi, E.L., Karlseder, J. TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells. (2023) iScience. 26(4):106405. DOI: 10.1016/j.isci.2023.106405

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Jones, C.Y., Williams, C.L., Moreno, S.P., Morris, D.K., Mondello, C., Karlseder, J., Bertuch, A.A. Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cells. (2023) Journal of Biological Chemistry.:104665 DOI: 10.1016/j.jbc.2023.104665

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Nassour, J., Aguiar, L.G., Correia, A., Schmidt, T., Mainz, L., Przetocka, S., Haggblom, C., Tadepalle, N., Williams, A., Shokhirev, M.N., Akincilar, S.C., Tergaonkar, V., Shadel, S., Karlseder, J. Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis (2023) Nature. DOI: https://doi.org/10.1038/s41586-023-05710-8

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Jones, C.Y., Williams, C.L., Moreno, S.P., Morris, D.K., Mondello, C., Karlseder, J., Bertuch, A.A. Hyperextended telomeres promote C-circle formation in telomerase positive human cells. (2023) bioRxiv. DOI: 10.1101/2023.01.26.525615

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Nassour, J., Schmidt, T.T., Karlseder, J. Telomeres and Cancer: Resolving the Paradox. (2021) Annu Rev Cancer Biol. 5(1):59-77. DOI: 10.1146/annurev-cancerbio-050420-023410

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Spinler, K., Bajaj, J., Ito, T., Zimdahl, B., Hamilton, M., Ahmadi, A., Koechlein, C.S., Lytle, N., Kwon, H.Y., Anower-E-Khuda, F., Sun, H., Blevins, A., Weeks, J., Kritzik, M., Karlseder, J., Ginsberg, M.H., Park, P.W., Esko, J.D., Reya, T. A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. (2020) Nature Communications. 11(1):5998. DOI: 10.1038/s41467-020-19782-x

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Masamsetti, V.P., Low, R.R.J., Mak, K.S., O’Connor, A., Riffkin, C.D., Lamm, N., Crabbe, L., Karlseder, J., Huang, D.C.S., Hayashi, M.T., Cesare, A.J. Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. (2019) Nature Communications. 10(1):4224. DOI: 10.1038/s41467-019-12255-w

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Nassour, J., Radford, R., Correia, A., Fusté, J.M., Schoell, B., Jauch, A., Shaw, R.J., Karlseder, J. Autophagic cell death restricts chromosomal instability during replicative crisis. (2019) Nature. 565(7741):659-663. DOI: 10.1038/s41586-019-0885-0

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Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C.W., Boulton, S.J., Saghatelian, A., Karlseder, J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. (2017) Nature. 549(7673):548-552. DOI: 10.1038/nature24023

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Li, J.S., Miralles Fusté, J., Simavorian, T., Bartocci, C., Tsai, J., Karlseder, J., Lazzerini Denchi, E. TZAP: A telomere-associated protein involved in telomere length control. (2017) Science. 355(6325):638-641. DOI: 10.1126/science.aah6752

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Rivera, T., Haggblom, C., Cosconati, S., Karlseder, J. A balance between elongation and trimming regulates telomere stability in stem cells. (2017) Nature Structural & Molecular Biology. 24(1):30-39. DOI: 10.1038/nsmb.3335

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Arnoult, N., Karlseder, J. Complex interactions between the DNA-damage response and mammalian telomeres. (2015) Nature Structural & Molecular Biology. 22(11):859-66. DOI: 10.1038/nsmb.3092

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Hayashi, M.T., Cesare, A.J., Rivera, T., Karlseder, J. Cell death during crisis is mediated by mitotic telomere deprotection. (2015) Nature. 522(7557):492-6. DOI: 10.1038/nature14513

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Lackner, D.H., Hayashi, M.T., Cesare, A.J., Karlseder, J. A genomics approach identifies senescence-specific gene expression regulation. (2014) Aging Cell. 13(5):946-50. DOI: 10.1111/acel.12234

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Arnoult, N., Karlseder, J. ALT telomeres borrow from meiosis to get moving. (2014) Cell. 159(1):11-2. DOI: 10.1016/j.cell.2014.09.013

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Karlseder, J. Modern genome editing meets telomeres: the many functions of TPP1. (2014) Genes & Development. 28(17):1857-8. DOI: 10.1101/gad.250316.114

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O’Sullivan, R.J., Arnoult, N., Lackner, D.H., Oganesian, L., Haggblom, C., Corpet, A., Almouzni, G., Karlseder, J. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. (2014) Nature Structural & Molecular Biology. 21(2):167-74. DOI: 10.1038/nsmb.2754

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Hayashi, M.T., Karlseder, J. DNA damage associated with mitosis and cytokinesis failure. (2013) Oncogene. 32(39):4593-601. DOI: 10.1038/onc.2012.615

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Cesare, A.J., Hayashi, M.T., Crabbe, L., Karlseder, J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. (2013) Molecular Cell. 51(2):141-55. DOI: 10.1016/j.molcel.2013.06.006

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Oganesian, L., Karlseder, J. 5′ C-rich telomeric overhangs are an outcome of rapid telomere truncation events. (2013) DNA Repair (Amst.). 12(3):238-45. DOI: 10.1016/j.dnarep.2012.12.008

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Lackner, D.H., Karlseder, J. C. elegans survivors without telomerase. (2013) Worm. 2(1):e21073. DOI: 10.4161/worm.21073

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Crabbe, L., Cesare, A.J., Kasuboski, J.M., Fitzpatrick, J.A., Karlseder, J. Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. (2012) Cell Reports. 2(6):1521-9. DOI: 10.1016/j.celrep.2012.11.019

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Cesare, A.J., Karlseder, J. A three-state model of telomere control over human proliferative boundaries. (2012) Current Opinion in Cell Biology. 24(6):731-8. DOI: 10.1016/j.ceb.2012.08.007

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O’Sullivan, R.J., Karlseder, J. The great unravelling: chromatin as a modulator of the aging process. (2012) Trends in Biochemical Sciences. 37(11):466-76. DOI: 10.1016/j.tibs.2012.08.001

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Barefield, C., Karlseder, J. The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. (2012) Nucleic Acids Research. 40(15):7358-67. DOI: 10.1093/nar/gks407

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Lackner, D.H., Raices, M., Maruyama, H., Haggblom, C., Karlseder, J. Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. (2012) EMBO Journal. 31(8):2024-33. DOI: 10.1038/emboj.2012.61

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Hayashi, M.T., Cesare, A.J., Fitzpatrick, J.A., Lazzerini-Denchi, E., Karlseder, J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. (2012) Nature Structural & Molecular Biology. 19(4):387-94. DOI: 10.1038/nsmb.2245

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Lackner, D.H., Durocher, D., Karlseder, J. A siRNA-based screen for genes involved in chromosome end protection. (2011) PLOS One. 6(6):e21407. DOI: 10.1371/journal.pone.0021407

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Oganesian, L., Karlseder, J. Mammalian 5′ C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. (2011) Molecular Cell. 42(2):224-36. DOI: 10.1016/j.molcel.2011.03.015

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Flynn, R.L., Centore, R.C., O’Sullivan, R.J., Rai, R., Tse, A., Songyang, Z., Chang, S., Karlseder, J., Zou, L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. (2011) Nature. 471(7339):532-6. DOI: 10.1038/nature09772

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Orazio, N.I., Naeger, C.M., Karlseder, J., Weitzman, M.D. The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. (2011) Journal of Virology. 85(4):1887-92. DOI: 10.1128/JVI.02134-10

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Corpet, A., De Koning, L., Toedling, J., Savignoni, A., Berger, F., Lemaître, C., O’Sullivan, R.J., Karlseder, J., Barillot, E., Asselain, B., Sastre-Garau, X., Almouzni, G. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. (2011) EMBO Journal. 30(3):480-93. DOI: 10.1038/emboj.2010.335

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O’Sullivan, R.J., Kubicek, S., Schreiber, S.L., Karlseder, J. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. (2010) Nature Structural & Molecular Biology. 17(10):1218-25. DOI: 10.1038/nsmb.1897

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Crabbe, L., Karlseder, J. Mammalian Rap1 widens its impact. (2010) Nature Cell Biology. 12(8):733-5. DOI: 10.1038/ncb2088


O’Sullivan, R.J., Karlseder, J. Telomeres: protecting chromosomes against genome instability. (2010) Nature Reviews Molecular Cell Biology. 11(3):171-81. DOI: 10.1038/nrm2848

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Blagosklonny, M.V., Campisi, J., Sinclair, D.A., Bartke, A., Blasco, M.A., Bonner, W.M., Bohr, V.A., Brosh, R.M., Brunet, A., Depinho, R.A., Donehower, L.A., Finch, C.E., Finkel, T., Gorospe, M., Gudkov, A.V., Hall, M.N., Hekimi, S., Helfand, S.L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H.D., Peeper, D.S., Rando, T.A., Rudolph, K.L., Sassone-Corsi, P., Serrano, M., Sharpless, N.E., Skulachev, V.P., Tilly, J.L., Tower, J., Verdin, E., Vijg, J. Impact papers on aging in 2009. (2010) Aging. 2(3):111-21. DOI: 10.18632/aging.100132

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Karlseder, J. Chromosome end protection becomes even more complex. (2009) Nature Structural & Molecular Biology. 16(12):1205-6. DOI: 10.1038/nsmb1209-1205


Oganesian, L., Karlseder, J. Telomeric armor: the layers of end protection. (2009) Journal of Cell Science. 122(Pt 22):4013-25. DOI: 10.1242/jcs.050567

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Sfeir, A., Kosiyatrakul, S.T., Hockemeyer, D., MacRae, S.L., Karlseder, J., Schildkraut, C.L., de Lange, T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. (2009) Cell. 138(1):90-103. DOI: 10.1016/j.cell.2009.06.021

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Begemann, S., Galimi, F., Karlseder, J. Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas. (2009) Aging. 1(1):122-130. DOI: 10.18632/aging.100015

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Raices, M., Verdun, R.E., Compton, S.A., Haggblom, C.I., Griffith, J.D., Dillin, A., Karlseder, J. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. (2008) Cell. 132(5):745-57. DOI: 10.1016/j.cell.2007.12.039

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Verdun, R.E., Karlseder, J. Replication and protection of telomeres. (2007) Nature. 447(7147):924-31. DOI: 10.1038/nature05976

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Karlseder, J., Cooper, J.P. Of wombats and whales: telomere tales in Madrid. Conference on telomeres and telomerase. (2007) EMBO Reports. 8(6):542-6. DOI: 10.1038/sj.embor.7400985


Crabbe, L., Jauch, A., Naeger, C.M., Holtgreve-Grez, H., Karlseder, J. Telomere dysfunction as a cause of genomic instability in Werner syndrome. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(7):2205-10. DOI: 10.1073/pnas.0609410104

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Verdun, R.E., Karlseder, J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. (2006) Cell. 127(4):709-20. DOI: 10.1016/j.cell.2006.09.034

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Karlseder, J. Telomeric proteins: clearing the way for the replication fork. (2006) Nature Structural & Molecular Biology. 13(5):386-7. DOI: 10.1038/nsmb0506-386

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Verdun, R.E., Crabbe, L., Haggblom, C., Karlseder, J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. (2005) Molecular Cell. 20(4):551-61. DOI: 10.1016/j.molcel.2005.09.024

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Raices, M., Maruyama, H., Dillin, A., Karlseder, J. Uncoupling of longevity and telomere length in C. elegans. (2005) PLOS Genetics. 1(3):e30. DOI: 10.1371/journal.pgen.0010030

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Crabbe, L., Karlseder, J. In the end, it’s all structure. (2005) Current Molecular Medicine. 5(2):135-43.

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Crabbe, L., Verdun, R.E., Haggblom, C.I., Karlseder, J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. (2004) Science. 306(5703):1951-3. DOI: 10.1126/science.1103619

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Karlseder, J., Hoke, K., Mirzoeva, O.K., Bakkenist, C., Kastan, M.B., Petrini, J.H., de Lange, T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. (2004) PLOS Biology. 2(8):E240. DOI: 10.1371/journal.pbio.0020240

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Karlseder, J., Kachatrian, L., Takai, H., Mercer, K., Hingorani, S., Jacks, T., de Lange, T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. (2003) Molecular and Cellular Biology. 23(18):6533-41.

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Karlseder, J. Telomere repeat binding factors: keeping the ends in check. (2003) Cancer Letters. 194(2):189-97.

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Smogorzewska, A., Karlseder, J., Holtgreve-Grez, H., Jauch, A., de Lange, T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. (2002) Current Biology. 12(19):1635-44.

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Karlseder, J., Smogorzewska, A., de Lange, T. Senescence induced by altered telomere state, not telomere loss. (2002) Science. 295(5564):2446-9. DOI: 10.1126/science.1069523

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Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., de Lange, T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. (1999) Science. 283(5406):1321-5.

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Wolschek, M.F., Narendja, F., Karlseder, J., Kubicek, C.P., Scazzocchio, C., Strauss, J. In situ detection of protein-DNA interactions in filamentous fungi by in vivo footprinting. (1998) Nucleic Acids Research. 26(16):3862-4.

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Orel, L., Simon, M.M., Karlseder, J., Bhardwaj, R., Trautinger, F., Schwarz, T., Luger, T.A. alpha-Melanocyte stimulating hormone downregulates differentiation-driven heat shock protein 70 expression in keratinocytes. (1997) Journal of Investigative Dermatology. 108(4):401-5.

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Sliutz, G., Karlseder, J., Tempfer, C., Orel, L., Holzer, G., Simon, M.M. Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. (1996) British Journal of Cancer. 74(2):172-7.

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Sutterluety, H., Bartl, S., Karlseder, J., Wintersberger, E., Seiser, C. Carboxy-terminal residues of mouse thymidine kinase are essential for rapid degradation in quiescent cells. (1996) Journal of Molecular Biology. 259(3):383-92. DOI: 10.1006/jmbi.1996.0327

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Karlseder, J., Rotheneder, H., Wintersberger, E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. (1996) Molecular and Cellular Biology. 16(4):1659-67.

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Karlseder, J., Wissing, D., Holzer, G., Orel, L., Sliutz, G., Auer, H., Jäättelä, M., Simon, M.M. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. (1996) Biochemical and Biophysical Research Communications. 220(1):153-9. DOI: 10.1006/bbrc.1996.0373

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Karlseder, J., Zeillinger, R., Schneeberger, C., Czerwenka, K., Speiser, P., Kubista, E., Birnbaum, D., Gaudray, P., Theillet, C. Patterns of DNA amplification at band q13 of chromosome 11 in human breast cancer. (1994) Genes Chromosomes Cancer. 9(1):42-8.

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