Publications

all Publications


Nassour, J., Przetocka, S., Karlseder, J. Telomeres as hotspots for innate immunity and inflammation. (2023) DNA Repair (Amst). 133:103591. DOI: 10.1016/j.dnarep.2023.103591

+ expand abstract

Moreno, S.P., Fusté, J.M., Kaiser, M., Li, J.S.Z., Nassour, J., Haggblom, C., Denchi, E.L., Karlseder, J. TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells. (2023) iScience. 26(4):106405. DOI: 10.1016/j.isci.2023.106405

+ expand abstract

Jones, C.Y., Williams, C.L., Moreno, S.P., Morris, D.K., Mondello, C., Karlseder, J., Bertuch, A.A. Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cells. (2023) Journal of Biological Chemistry.:104665 DOI: 10.1016/j.jbc.2023.104665

+ expand abstract

Nassour, J., Aguiar, L.G., Correia, A., Schmidt, T., Mainz, L., Przetocka, S., Haggblom, C., Tadepalle, N., Williams, A., Shokhirev, M.N., Akincilar, S.C., Tergaonkar, V., Shadel, S., Karlseder, J. Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis (2023) Nature. DOI: https://doi.org/10.1038/s41586-023-05710-8

+ expand abstract

Jones, C.Y., Williams, C.L., Moreno, S.P., Morris, D.K., Mondello, C., Karlseder, J., Bertuch, A.A. Hyperextended telomeres promote C-circle formation in telomerase positive human cells. (2023) bioRxiv. DOI: 10.1101/2023.01.26.525615

+ expand abstract

Nassour, J., Schmidt, T.T., Karlseder, J. Telomeres and Cancer: Resolving the Paradox. (2021) Annu Rev Cancer Biol. 5(1):59-77. DOI: 10.1146/annurev-cancerbio-050420-023410

+ expand abstract

Spinler, K., Bajaj, J., Ito, T., Zimdahl, B., Hamilton, M., Ahmadi, A., Koechlein, C.S., Lytle, N., Kwon, H.Y., Anower-E-Khuda, F., Sun, H., Blevins, A., Weeks, J., Kritzik, M., Karlseder, J., Ginsberg, M.H., Park, P.W., Esko, J.D., Reya, T. A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. (2020) Nature Communications. 11(1):5998. DOI: 10.1038/s41467-020-19782-x

+ expand abstract

Masamsetti, V.P., Low, R.R.J., Mak, K.S., O’Connor, A., Riffkin, C.D., Lamm, N., Crabbe, L., Karlseder, J., Huang, D.C.S., Hayashi, M.T., Cesare, A.J. Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. (2019) Nature Communications. 10(1):4224. DOI: 10.1038/s41467-019-12255-w

+ expand abstract

Nassour, J., Radford, R., Correia, A., Fusté, J.M., Schoell, B., Jauch, A., Shaw, R.J., Karlseder, J. Autophagic cell death restricts chromosomal instability during replicative crisis. (2019) Nature. 565(7741):659-663. DOI: 10.1038/s41586-019-0885-0

+ expand abstract

Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C.W., Boulton, S.J., Saghatelian, A., Karlseder, J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. (2017) Nature. 549(7673):548-552. DOI: 10.1038/nature24023

+ expand abstract

Li, J.S., Miralles Fusté, J., Simavorian, T., Bartocci, C., Tsai, J., Karlseder, J., Lazzerini Denchi, E. TZAP: A telomere-associated protein involved in telomere length control. (2017) Science. 355(6325):638-641. DOI: 10.1126/science.aah6752

+ expand abstract

Rivera, T., Haggblom, C., Cosconati, S., Karlseder, J. A balance between elongation and trimming regulates telomere stability in stem cells. (2017) Nature Structural & Molecular Biology. 24(1):30-39. DOI: 10.1038/nsmb.3335

+ expand abstract

Arnoult, N., Karlseder, J. Complex interactions between the DNA-damage response and mammalian telomeres. (2015) Nature Structural & Molecular Biology. 22(11):859-66. DOI: 10.1038/nsmb.3092

+ expand abstract

Hayashi, M.T., Cesare, A.J., Rivera, T., Karlseder, J. Cell death during crisis is mediated by mitotic telomere deprotection. (2015) Nature. 522(7557):492-6. DOI: 10.1038/nature14513

+ expand abstract

Lackner, D.H., Hayashi, M.T., Cesare, A.J., Karlseder, J. A genomics approach identifies senescence-specific gene expression regulation. (2014) Aging Cell. 13(5):946-50. DOI: 10.1111/acel.12234

+ expand abstract

Arnoult, N., Karlseder, J. ALT telomeres borrow from meiosis to get moving. (2014) Cell. 159(1):11-2. DOI: 10.1016/j.cell.2014.09.013

+ expand abstract

Karlseder, J. Modern genome editing meets telomeres: the many functions of TPP1. (2014) Genes & Development. 28(17):1857-8. DOI: 10.1101/gad.250316.114

+ expand abstract

O’Sullivan, R.J., Arnoult, N., Lackner, D.H., Oganesian, L., Haggblom, C., Corpet, A., Almouzni, G., Karlseder, J. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. (2014) Nature Structural & Molecular Biology. 21(2):167-74. DOI: 10.1038/nsmb.2754

+ expand abstract

Hayashi, M.T., Karlseder, J. DNA damage associated with mitosis and cytokinesis failure. (2013) Oncogene. 32(39):4593-601. DOI: 10.1038/onc.2012.615

+ expand abstract

Cesare, A.J., Hayashi, M.T., Crabbe, L., Karlseder, J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. (2013) Molecular Cell. 51(2):141-55. DOI: 10.1016/j.molcel.2013.06.006

+ expand abstract

Oganesian, L., Karlseder, J. 5′ C-rich telomeric overhangs are an outcome of rapid telomere truncation events. (2013) DNA Repair (Amst.). 12(3):238-45. DOI: 10.1016/j.dnarep.2012.12.008

+ expand abstract

Lackner, D.H., Karlseder, J. C. elegans survivors without telomerase. (2013) Worm. 2(1):e21073. DOI: 10.4161/worm.21073

+ expand abstract

Crabbe, L., Cesare, A.J., Kasuboski, J.M., Fitzpatrick, J.A., Karlseder, J. Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. (2012) Cell Reports. 2(6):1521-9. DOI: 10.1016/j.celrep.2012.11.019

+ expand abstract

Cesare, A.J., Karlseder, J. A three-state model of telomere control over human proliferative boundaries. (2012) Current Opinion in Cell Biology. 24(6):731-8. DOI: 10.1016/j.ceb.2012.08.007

+ expand abstract

O’Sullivan, R.J., Karlseder, J. The great unravelling: chromatin as a modulator of the aging process. (2012) Trends in Biochemical Sciences. 37(11):466-76. DOI: 10.1016/j.tibs.2012.08.001

+ expand abstract

Barefield, C., Karlseder, J. The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. (2012) Nucleic Acids Research. 40(15):7358-67. DOI: 10.1093/nar/gks407

+ expand abstract

Lackner, D.H., Raices, M., Maruyama, H., Haggblom, C., Karlseder, J. Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. (2012) EMBO Journal. 31(8):2024-33. DOI: 10.1038/emboj.2012.61

+ expand abstract

Hayashi, M.T., Cesare, A.J., Fitzpatrick, J.A., Lazzerini-Denchi, E., Karlseder, J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. (2012) Nature Structural & Molecular Biology. 19(4):387-94. DOI: 10.1038/nsmb.2245

+ expand abstract

Lackner, D.H., Durocher, D., Karlseder, J. A siRNA-based screen for genes involved in chromosome end protection. (2011) PLOS One. 6(6):e21407. DOI: 10.1371/journal.pone.0021407

+ expand abstract

Oganesian, L., Karlseder, J. Mammalian 5′ C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. (2011) Molecular Cell. 42(2):224-36. DOI: 10.1016/j.molcel.2011.03.015

+ expand abstract

Flynn, R.L., Centore, R.C., O’Sullivan, R.J., Rai, R., Tse, A., Songyang, Z., Chang, S., Karlseder, J., Zou, L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. (2011) Nature. 471(7339):532-6. DOI: 10.1038/nature09772

+ expand abstract

Orazio, N.I., Naeger, C.M., Karlseder, J., Weitzman, M.D. The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. (2011) Journal of Virology. 85(4):1887-92. DOI: 10.1128/JVI.02134-10

+ expand abstract

Corpet, A., De Koning, L., Toedling, J., Savignoni, A., Berger, F., Lemaître, C., O’Sullivan, R.J., Karlseder, J., Barillot, E., Asselain, B., Sastre-Garau, X., Almouzni, G. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. (2011) EMBO Journal. 30(3):480-93. DOI: 10.1038/emboj.2010.335

+ expand abstract

O’Sullivan, R.J., Kubicek, S., Schreiber, S.L., Karlseder, J. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. (2010) Nature Structural & Molecular Biology. 17(10):1218-25. DOI: 10.1038/nsmb.1897

+ expand abstract

Crabbe, L., Karlseder, J. Mammalian Rap1 widens its impact. (2010) Nature Cell Biology. 12(8):733-5. DOI: 10.1038/ncb2088


O’Sullivan, R.J., Karlseder, J. Telomeres: protecting chromosomes against genome instability. (2010) Nature Reviews Molecular Cell Biology. 11(3):171-81. DOI: 10.1038/nrm2848

+ expand abstract

Blagosklonny, M.V., Campisi, J., Sinclair, D.A., Bartke, A., Blasco, M.A., Bonner, W.M., Bohr, V.A., Brosh, R.M., Brunet, A., Depinho, R.A., Donehower, L.A., Finch, C.E., Finkel, T., Gorospe, M., Gudkov, A.V., Hall, M.N., Hekimi, S., Helfand, S.L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H.D., Peeper, D.S., Rando, T.A., Rudolph, K.L., Sassone-Corsi, P., Serrano, M., Sharpless, N.E., Skulachev, V.P., Tilly, J.L., Tower, J., Verdin, E., Vijg, J. Impact papers on aging in 2009. (2010) Aging. 2(3):111-21. DOI: 10.18632/aging.100132

+ expand abstract

Karlseder, J. Chromosome end protection becomes even more complex. (2009) Nature Structural & Molecular Biology. 16(12):1205-6. DOI: 10.1038/nsmb1209-1205


Oganesian, L., Karlseder, J. Telomeric armor: the layers of end protection. (2009) Journal of Cell Science. 122(Pt 22):4013-25. DOI: 10.1242/jcs.050567

+ expand abstract

Sfeir, A., Kosiyatrakul, S.T., Hockemeyer, D., MacRae, S.L., Karlseder, J., Schildkraut, C.L., de Lange, T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. (2009) Cell. 138(1):90-103. DOI: 10.1016/j.cell.2009.06.021

+ expand abstract

Begemann, S., Galimi, F., Karlseder, J. Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas. (2009) Aging. 1(1):122-130. DOI: 10.18632/aging.100015

+ expand abstract

Raices, M., Verdun, R.E., Compton, S.A., Haggblom, C.I., Griffith, J.D., Dillin, A., Karlseder, J. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. (2008) Cell. 132(5):745-57. DOI: 10.1016/j.cell.2007.12.039

+ expand abstract

Verdun, R.E., Karlseder, J. Replication and protection of telomeres. (2007) Nature. 447(7147):924-31. DOI: 10.1038/nature05976

+ expand abstract

Karlseder, J., Cooper, J.P. Of wombats and whales: telomere tales in Madrid. Conference on telomeres and telomerase. (2007) EMBO Reports. 8(6):542-6. DOI: 10.1038/sj.embor.7400985


Crabbe, L., Jauch, A., Naeger, C.M., Holtgreve-Grez, H., Karlseder, J. Telomere dysfunction as a cause of genomic instability in Werner syndrome. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(7):2205-10. DOI: 10.1073/pnas.0609410104

+ expand abstract

Verdun, R.E., Karlseder, J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. (2006) Cell. 127(4):709-20. DOI: 10.1016/j.cell.2006.09.034

+ expand abstract

Karlseder, J. Telomeric proteins: clearing the way for the replication fork. (2006) Nature Structural & Molecular Biology. 13(5):386-7. DOI: 10.1038/nsmb0506-386

+ expand abstract

Verdun, R.E., Crabbe, L., Haggblom, C., Karlseder, J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. (2005) Molecular Cell. 20(4):551-61. DOI: 10.1016/j.molcel.2005.09.024

+ expand abstract

Raices, M., Maruyama, H., Dillin, A., Karlseder, J. Uncoupling of longevity and telomere length in C. elegans. (2005) PLOS Genetics. 1(3):e30. DOI: 10.1371/journal.pgen.0010030

+ expand abstract

Crabbe, L., Karlseder, J. In the end, it’s all structure. (2005) Current Molecular Medicine. 5(2):135-43.

+ expand abstract

Crabbe, L., Verdun, R.E., Haggblom, C.I., Karlseder, J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. (2004) Science. 306(5703):1951-3. DOI: 10.1126/science.1103619

+ expand abstract

Karlseder, J., Hoke, K., Mirzoeva, O.K., Bakkenist, C., Kastan, M.B., Petrini, J.H., de Lange, T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. (2004) PLOS Biology. 2(8):E240. DOI: 10.1371/journal.pbio.0020240

+ expand abstract

Karlseder, J., Kachatrian, L., Takai, H., Mercer, K., Hingorani, S., Jacks, T., de Lange, T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. (2003) Molecular and Cellular Biology. 23(18):6533-41.

+ expand abstract

Karlseder, J. Telomere repeat binding factors: keeping the ends in check. (2003) Cancer Letters. 194(2):189-97.

+ expand abstract

Smogorzewska, A., Karlseder, J., Holtgreve-Grez, H., Jauch, A., de Lange, T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. (2002) Current Biology. 12(19):1635-44.

+ expand abstract

Karlseder, J., Smogorzewska, A., de Lange, T. Senescence induced by altered telomere state, not telomere loss. (2002) Science. 295(5564):2446-9. DOI: 10.1126/science.1069523

+ expand abstract

Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., de Lange, T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. (1999) Science. 283(5406):1321-5.

+ expand abstract

Wolschek, M.F., Narendja, F., Karlseder, J., Kubicek, C.P., Scazzocchio, C., Strauss, J. In situ detection of protein-DNA interactions in filamentous fungi by in vivo footprinting. (1998) Nucleic Acids Research. 26(16):3862-4.

+ expand abstract

Orel, L., Simon, M.M., Karlseder, J., Bhardwaj, R., Trautinger, F., Schwarz, T., Luger, T.A. alpha-Melanocyte stimulating hormone downregulates differentiation-driven heat shock protein 70 expression in keratinocytes. (1997) Journal of Investigative Dermatology. 108(4):401-5.

+ expand abstract

Sliutz, G., Karlseder, J., Tempfer, C., Orel, L., Holzer, G., Simon, M.M. Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. (1996) British Journal of Cancer. 74(2):172-7.

+ expand abstract

Sutterluety, H., Bartl, S., Karlseder, J., Wintersberger, E., Seiser, C. Carboxy-terminal residues of mouse thymidine kinase are essential for rapid degradation in quiescent cells. (1996) Journal of Molecular Biology. 259(3):383-92. DOI: 10.1006/jmbi.1996.0327

+ expand abstract

Karlseder, J., Rotheneder, H., Wintersberger, E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. (1996) Molecular and Cellular Biology. 16(4):1659-67.

+ expand abstract

Karlseder, J., Wissing, D., Holzer, G., Orel, L., Sliutz, G., Auer, H., Jäättelä, M., Simon, M.M. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. (1996) Biochemical and Biophysical Research Communications. 220(1):153-9. DOI: 10.1006/bbrc.1996.0373

+ expand abstract

Karlseder, J., Zeillinger, R., Schneeberger, C., Czerwenka, K., Speiser, P., Kubista, E., Birnbaum, D., Gaudray, P., Theillet, C. Patterns of DNA amplification at band q13 of chromosome 11 in human breast cancer. (1994) Genes Chromosomes Cancer. 9(1):42-8.

+ expand abstract