all Publications

Schmidt, T.T., Tyer, C., Rughani, P., Haggblom, C., Jones, J.R., Dai, X., Frazer, K.A., Gage, F.H., Juul, S., Hickey, S., Karlseder, J. High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer. (2024) Nature Communications. 15(1):5149. DOI: 10.1038/s41467-024-48917-7

Nassour, J., Przetocka, S., Karlseder, J. Telomeres as hotspots for innate immunity and inflammation. (2023) DNA Repair (Amst). 133:103591. DOI: 10.1016/j.dnarep.2023.103591

Moreno, S.P., Fusté, J.M., Kaiser, M., Li, J.S.Z., Nassour, J., Haggblom, C., Denchi, E.L., Karlseder, J. TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells. (2023) iScience. 26(4):106405. DOI: 10.1016/j.isci.2023.106405

Jones, C.Y., Williams, C.L., Moreno, S.P., Morris, D.K., Mondello, C., Karlseder, J., Bertuch, A.A. Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cells. (2023) Journal of Biological Chemistry.:104665 DOI: 10.1016/j.jbc.2023.104665

Nassour, J., Aguiar, L.G., Correia, A., Schmidt, T., Mainz, L., Przetocka, S., Haggblom, C., Tadepalle, N., Williams, A., Shokhirev, M.N., Akincilar, S.C., Tergaonkar, V., Shadel, S., Karlseder, J. Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis (2023) Nature. DOI: https://doi.org/10.1038/s41586-023-05710-8

Jones, C.Y., Williams, C.L., Moreno, S.P., Morris, D.K., Mondello, C., Karlseder, J., Bertuch, A.A. Hyperextended telomeres promote C-circle formation in telomerase positive human cells. (2023) bioRxiv. DOI: 10.1101/2023.01.26.525615

Nassour, J., Schmidt, T.T., Karlseder, J. Telomeres and Cancer: Resolving the Paradox. (2021) Annu Rev Cancer Biol. 5(1):59-77. DOI: 10.1146/annurev-cancerbio-050420-023410

Spinler, K., Bajaj, J., Ito, T., Zimdahl, B., Hamilton, M., Ahmadi, A., Koechlein, C.S., Lytle, N., Kwon, H.Y., Anower-E-Khuda, F., Sun, H., Blevins, A., Weeks, J., Kritzik, M., Karlseder, J., Ginsberg, M.H., Park, P.W., Esko, J.D., Reya, T. A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. (2020) Nature Communications. 11(1):5998. DOI: 10.1038/s41467-020-19782-x

Masamsetti, V.P., Low, R.R.J., Mak, K.S., O’Connor, A., Riffkin, C.D., Lamm, N., Crabbe, L., Karlseder, J., Huang, D.C.S., Hayashi, M.T., Cesare, A.J. Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. (2019) Nature Communications. 10(1):4224. DOI: 10.1038/s41467-019-12255-w

Nassour, J., Radford, R., Correia, A., Fusté, J.M., Schoell, B., Jauch, A., Shaw, R.J., Karlseder, J. Autophagic cell death restricts chromosomal instability during replicative crisis. (2019) Nature. 565(7741):659-663. DOI: 10.1038/s41586-019-0885-0

Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C.W., Boulton, S.J., Saghatelian, A., Karlseder, J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. (2017) Nature. 549(7673):548-552. DOI: 10.1038/nature24023

Li, J.S., Miralles Fusté, J., Simavorian, T., Bartocci, C., Tsai, J., Karlseder, J., Lazzerini Denchi, E. TZAP: A telomere-associated protein involved in telomere length control. (2017) Science. 355(6325):638-641. DOI: 10.1126/science.aah6752

Rivera, T., Haggblom, C., Cosconati, S., Karlseder, J. A balance between elongation and trimming regulates telomere stability in stem cells. (2017) Nature Structural & Molecular Biology. 24(1):30-39. DOI: 10.1038/nsmb.3335

Arnoult, N., Karlseder, J. Complex interactions between the DNA-damage response and mammalian telomeres. (2015) Nature Structural & Molecular Biology. 22(11):859-66. DOI: 10.1038/nsmb.3092

Hayashi, M.T., Cesare, A.J., Rivera, T., Karlseder, J. Cell death during crisis is mediated by mitotic telomere deprotection. (2015) Nature. 522(7557):492-6. DOI: 10.1038/nature14513

Lackner, D.H., Hayashi, M.T., Cesare, A.J., Karlseder, J. A genomics approach identifies senescence-specific gene expression regulation. (2014) Aging Cell. 13(5):946-50. DOI: 10.1111/acel.12234

Arnoult, N., Karlseder, J. ALT telomeres borrow from meiosis to get moving. (2014) Cell. 159(1):11-2. DOI: 10.1016/j.cell.2014.09.013

Karlseder, J. Modern genome editing meets telomeres: the many functions of TPP1. (2014) Genes & Development. 28(17):1857-8. DOI: 10.1101/gad.250316.114

O’Sullivan, R.J., Arnoult, N., Lackner, D.H., Oganesian, L., Haggblom, C., Corpet, A., Almouzni, G., Karlseder, J. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. (2014) Nature Structural & Molecular Biology. 21(2):167-74. DOI: 10.1038/nsmb.2754

Hayashi, M.T., Karlseder, J. DNA damage associated with mitosis and cytokinesis failure. (2013) Oncogene. 32(39):4593-601. DOI: 10.1038/onc.2012.615

Cesare, A.J., Hayashi, M.T., Crabbe, L., Karlseder, J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. (2013) Molecular Cell. 51(2):141-55. DOI: 10.1016/j.molcel.2013.06.006

Oganesian, L., Karlseder, J. 5′ C-rich telomeric overhangs are an outcome of rapid telomere truncation events. (2013) DNA Repair (Amst.). 12(3):238-45. DOI: 10.1016/j.dnarep.2012.12.008

Lackner, D.H., Karlseder, J. C. elegans survivors without telomerase. (2013) Worm. 2(1):e21073. DOI: 10.4161/worm.21073

Crabbe, L., Cesare, A.J., Kasuboski, J.M., Fitzpatrick, J.A., Karlseder, J. Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. (2012) Cell Reports. 2(6):1521-9. DOI: 10.1016/j.celrep.2012.11.019

Cesare, A.J., Karlseder, J. A three-state model of telomere control over human proliferative boundaries. (2012) Current Opinion in Cell Biology. 24(6):731-8. DOI: 10.1016/j.ceb.2012.08.007

O’Sullivan, R.J., Karlseder, J. The great unravelling: chromatin as a modulator of the aging process. (2012) Trends in Biochemical Sciences. 37(11):466-76. DOI: 10.1016/j.tibs.2012.08.001

Barefield, C., Karlseder, J. The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. (2012) Nucleic Acids Research. 40(15):7358-67. DOI: 10.1093/nar/gks407

Lackner, D.H., Raices, M., Maruyama, H., Haggblom, C., Karlseder, J. Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. (2012) EMBO Journal. 31(8):2024-33. DOI: 10.1038/emboj.2012.61

Hayashi, M.T., Cesare, A.J., Fitzpatrick, J.A., Lazzerini-Denchi, E., Karlseder, J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. (2012) Nature Structural & Molecular Biology. 19(4):387-94. DOI: 10.1038/nsmb.2245

Lackner, D.H., Durocher, D., Karlseder, J. A siRNA-based screen for genes involved in chromosome end protection. (2011) PLOS One. 6(6):e21407. DOI: 10.1371/journal.pone.0021407

Oganesian, L., Karlseder, J. Mammalian 5′ C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. (2011) Molecular Cell. 42(2):224-36. DOI: 10.1016/j.molcel.2011.03.015

Flynn, R.L., Centore, R.C., O’Sullivan, R.J., Rai, R., Tse, A., Songyang, Z., Chang, S., Karlseder, J., Zou, L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. (2011) Nature. 471(7339):532-6. DOI: 10.1038/nature09772

Orazio, N.I., Naeger, C.M., Karlseder, J., Weitzman, M.D. The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. (2011) Journal of Virology. 85(4):1887-92. DOI: 10.1128/JVI.02134-10

Corpet, A., De Koning, L., Toedling, J., Savignoni, A., Berger, F., Lemaître, C., O’Sullivan, R.J., Karlseder, J., Barillot, E., Asselain, B., Sastre-Garau, X., Almouzni, G. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. (2011) EMBO Journal. 30(3):480-93. DOI: 10.1038/emboj.2010.335

O’Sullivan, R.J., Kubicek, S., Schreiber, S.L., Karlseder, J. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. (2010) Nature Structural & Molecular Biology. 17(10):1218-25. DOI: 10.1038/nsmb.1897

Crabbe, L., Karlseder, J. Mammalian Rap1 widens its impact. (2010) Nature Cell Biology. 12(8):733-5. DOI: 10.1038/ncb2088

O’Sullivan, R.J., Karlseder, J. Telomeres: protecting chromosomes against genome instability. (2010) Nature Reviews Molecular Cell Biology. 11(3):171-81. DOI: 10.1038/nrm2848

Blagosklonny, M.V., Campisi, J., Sinclair, D.A., Bartke, A., Blasco, M.A., Bonner, W.M., Bohr, V.A., Brosh, R.M., Brunet, A., Depinho, R.A., Donehower, L.A., Finch, C.E., Finkel, T., Gorospe, M., Gudkov, A.V., Hall, M.N., Hekimi, S., Helfand, S.L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H.D., Peeper, D.S., Rando, T.A., Rudolph, K.L., Sassone-Corsi, P., Serrano, M., Sharpless, N.E., Skulachev, V.P., Tilly, J.L., Tower, J., Verdin, E., Vijg, J. Impact papers on aging in 2009. (2010) Aging. 2(3):111-21. DOI: 10.18632/aging.100132

Karlseder, J. Chromosome end protection becomes even more complex. (2009) Nature Structural & Molecular Biology. 16(12):1205-6. DOI: 10.1038/nsmb1209-1205

Oganesian, L., Karlseder, J. Telomeric armor: the layers of end protection. (2009) Journal of Cell Science. 122(Pt 22):4013-25. DOI: 10.1242/jcs.050567

Sfeir, A., Kosiyatrakul, S.T., Hockemeyer, D., MacRae, S.L., Karlseder, J., Schildkraut, C.L., de Lange, T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. (2009) Cell. 138(1):90-103. DOI: 10.1016/j.cell.2009.06.021

Begemann, S., Galimi, F., Karlseder, J. Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas. (2009) Aging. 1(1):122-130. DOI: 10.18632/aging.100015

Raices, M., Verdun, R.E., Compton, S.A., Haggblom, C.I., Griffith, J.D., Dillin, A., Karlseder, J. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. (2008) Cell. 132(5):745-57. DOI: 10.1016/j.cell.2007.12.039

Verdun, R.E., Karlseder, J. Replication and protection of telomeres. (2007) Nature. 447(7147):924-31. DOI: 10.1038/nature05976

Karlseder, J., Cooper, J.P. Of wombats and whales: telomere tales in Madrid. Conference on telomeres and telomerase. (2007) EMBO Reports. 8(6):542-6. DOI: 10.1038/sj.embor.7400985

Crabbe, L., Jauch, A., Naeger, C.M., Holtgreve-Grez, H., Karlseder, J. Telomere dysfunction as a cause of genomic instability in Werner syndrome. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(7):2205-10. DOI: 10.1073/pnas.0609410104

Verdun, R.E., Karlseder, J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. (2006) Cell. 127(4):709-20. DOI: 10.1016/j.cell.2006.09.034

Karlseder, J. Telomeric proteins: clearing the way for the replication fork. (2006) Nature Structural & Molecular Biology. 13(5):386-7. DOI: 10.1038/nsmb0506-386

Verdun, R.E., Crabbe, L., Haggblom, C., Karlseder, J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. (2005) Molecular Cell. 20(4):551-61. DOI: 10.1016/j.molcel.2005.09.024

Raices, M., Maruyama, H., Dillin, A., Karlseder, J. Uncoupling of longevity and telomere length in C. elegans. (2005) PLOS Genetics. 1(3):e30. DOI: 10.1371/journal.pgen.0010030

Crabbe, L., Karlseder, J. In the end, it’s all structure. (2005) Current Molecular Medicine. 5(2):135-43.

Crabbe, L., Verdun, R.E., Haggblom, C.I., Karlseder, J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. (2004) Science. 306(5703):1951-3. DOI: 10.1126/science.1103619

Karlseder, J., Hoke, K., Mirzoeva, O.K., Bakkenist, C., Kastan, M.B., Petrini, J.H., de Lange, T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. (2004) PLOS Biology. 2(8):E240. DOI: 10.1371/journal.pbio.0020240

Karlseder, J., Kachatrian, L., Takai, H., Mercer, K., Hingorani, S., Jacks, T., de Lange, T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. (2003) Molecular and Cellular Biology. 23(18):6533-41.

Karlseder, J. Telomere repeat binding factors: keeping the ends in check. (2003) Cancer Letters. 194(2):189-97.

Smogorzewska, A., Karlseder, J., Holtgreve-Grez, H., Jauch, A., de Lange, T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. (2002) Current Biology. 12(19):1635-44.

Karlseder, J., Smogorzewska, A., de Lange, T. Senescence induced by altered telomere state, not telomere loss. (2002) Science. 295(5564):2446-9. DOI: 10.1126/science.1069523

Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., de Lange, T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. (1999) Science. 283(5406):1321-5.

Wolschek, M.F., Narendja, F., Karlseder, J., Kubicek, C.P., Scazzocchio, C., Strauss, J. In situ detection of protein-DNA interactions in filamentous fungi by in vivo footprinting. (1998) Nucleic Acids Research. 26(16):3862-4.

Orel, L., Simon, M.M., Karlseder, J., Bhardwaj, R., Trautinger, F., Schwarz, T., Luger, T.A. alpha-Melanocyte stimulating hormone downregulates differentiation-driven heat shock protein 70 expression in keratinocytes. (1997) Journal of Investigative Dermatology. 108(4):401-5.

Sliutz, G., Karlseder, J., Tempfer, C., Orel, L., Holzer, G., Simon, M.M. Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. (1996) British Journal of Cancer. 74(2):172-7.

Sutterluety, H., Bartl, S., Karlseder, J., Wintersberger, E., Seiser, C. Carboxy-terminal residues of mouse thymidine kinase are essential for rapid degradation in quiescent cells. (1996) Journal of Molecular Biology. 259(3):383-92. DOI: 10.1006/jmbi.1996.0327

Karlseder, J., Rotheneder, H., Wintersberger, E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. (1996) Molecular and Cellular Biology. 16(4):1659-67.

Karlseder, J., Wissing, D., Holzer, G., Orel, L., Sliutz, G., Auer, H., Jäättelä, M., Simon, M.M. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. (1996) Biochemical and Biophysical Research Communications. 220(1):153-9. DOI: 10.1006/bbrc.1996.0373

Karlseder, J., Zeillinger, R., Schneeberger, C., Czerwenka, K., Speiser, P., Kubista, E., Birnbaum, D., Gaudray, P., Theillet, C. Patterns of DNA amplification at band q13 of chromosome 11 in human breast cancer. (1994) Genes Chromosomes Cancer. 9(1):42-8.